Gene expression profile from short-term caloric restriction in mouse adipose tissue

ABSTRACT: To provide a robust understanding of a transcriptomic change by short-term CR at body fat of mice, we applied three serial strengths of CR to mice including 15%, 30%, and 45% reduction of carbon source. Using Affymetrix mouse 1.0 ST array platform, we obtained and analyzed the transcriptome data for significantly changed genes in expression. Here, we identified 446 genes and categorized the genes based on their biological roles. We observed gradual down-regulation of several signaling pathways including insulin/insulin-like growth factor (IGF) 1, epidermal growth factor (EGF), transforming growth factor beta (TGF-β) and canonical Wingless-type mouse mammary tumor virus integration site (Wnt) signaling according to the CR strengths. Many genes related to structural feature including extrac

ORGANISM(S): Mus musculus

SUBMITTER: Cheol-Koo Lee 

PROVIDER: E-GEOD-60596 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress