Transcriptome and translatome profiling of CPX 90m effects in neuroblastoma cells CHP134

ABSTRACT: Neuroblastoma (NB) is the most frequent extracranial solid tumour of childhood. Clinical courses are highly variable, ranging from spontaneous regression/maturation to rapid progression despite intensive multimodal therapy. The estimation of 5-year event free survival in high-risk patients of only about 40 % stresses an importance of novel therapeutic strategies. A number of iron chelators have demonstrated marked in vitro and in vivo anti-tumor activity and are currently being developed as novel anti-cancer agents. Therefore, the potential antitumor effect of iron chelators in NB cancer was investigated. Among the compounds tested, ciclopirox olamine (CPX) was shown to be one of the most effective intracellular iron chelators in NB cells. To unveil the molecular mechanisms underlying the

ORGANISM(S): Homo sapiens

SUBMITTER: Toma Tebaldi 

PROVIDER: E-GEOD-60675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress