Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

ABSTRACT: Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in brain and has been implicated in DNA methylation-related plasticity. To identify the role of 5hmC in gene-environment interactions, we exposed both young (6-week-old) and aged (18-month-old) mice to both an enriched environment and a standard environment. Exposure to EE significantly improves learning and memory in aged mice and reduces 5hmC abundance in mouse hippocampus. Furthermore, we mapped the genome-wide distribution of 5hmC and found that the alteration of 5hmC modification occurred mainly at gene bodies. In p

ORGANISM(S): Mus musculus

SUBMITTER: Bing Yao 

PROVIDER: E-GEOD-61194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress