Leo1 is a Global Regulator of Heterochromatin Cis-spreading

ABSTRACT: Domains of heterochromatin play important roles in the maintenance and regulation of eukaryotic genomes. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates the existence of robust mechanisms that limit heterochromatin spreading and thereby avoid silencing of expressed genes. A number of specific sequence elements have been found to serve as barriers to heterochromatin spreading; however, the mechanisms by which spreading is curtailed are generally not well understood. Here we uncover a role for PAF complex component Leo1 in regulating heterochromatin cis-spreading. A genetic screen revealed that loss of Leo1 results in spreading of heterochromatin across a centromeric (IRC) boundary element in fission yeast. Similar heterochromatin

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Shaun Webb 

PROVIDER: E-GEOD-61688 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress