Transcription profiling of mouse mucosal mast cell in vitro differentiation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Zoltan Wiener
PROVIDER: E-GEOD-6192 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
HtrA1 is a novel mast cell serine protease of mice and men.
Gilicze Anna A Kohalmi Barbara B Pocza Peter P Keszei Marton M Jaeger Judit J Gorbe Eva E Papp Zoltan Z Toth Sara S Falus Andras A Wiener Zoltan Z
Molecular immunology 20070212 11
Mast cells are rich sources of proteases, such as tryptases and chymases that control many physiological and pathological processes, for example vascular permeability, smooth muscle cell proliferation or extracellular matrix remodeling. Murine mucosal mast cells mature under the influence of TGF-beta and play a role in asthmatic and anti-helminthic immune responses. In an attempt to identify novel genes that are highly upregulated during mucosal mast cell differentiation, we detected HtrA1 prote ...[more]
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