ChIP-seq analyses of the Aspergillus fumigatus SREBP SrbA

ABSTRACT: The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence in murine models of invasive pulmonary aspergillosis (IPA). How fungal SREBPs mediate fungal virulence is unknown, though it has been suggested that lack of growth in hypoxic conditions accounts for the attenuated virulence. To further understand the role of SrbA in fungal infection site pathobiology, chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-seq) was used to identify genes under direct SrbA transcriptional regulation in hypoxia. These r

ORGANISM(S): Aspergillus fumigatus

SUBMITTER: Bridget Barker 

PROVIDER: E-GEOD-61974 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress