Host microbiota constantly control maturation and function of microglia in the central nervous system (part 1)

ABSTRACT: As tissue macrophages of the central nervous system (CNS), microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. Here we reveal significant contributions of the host microbiota to microglia homeostasis as germ-free (GF) mice displayed global defects in microglia with altered cell proportions and an immature phenotype leading to impaired innate immune responses. Temporal eradication of host microbiota severely changed microglia properties. Limited microbiota complexity also resulted in defective microglia. In contrast, recolonization with a complex microbiota partially restored microglia features. We determined that short-chain fatty acids (SCFA), microbiota-derived bacterial fermenta

ORGANISM(S): Mus musculus

SUBMITTER: Ori Staszewski 

PROVIDER: E-GEOD-62201 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress