Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Effect of glucose, endothelin-1 and cortisol on human iPS-derived cardiomyocytes

ABSTRACT: Analysis of human iPS-derived cardiomyocytes exposed to glucose, endothelin-1 and cortisol in vitro. Treatment produces a surrogate diabetic cardiomyopathic phenotype. Results provide insight into the pathways regulated by the treatment in the cardiomyocyte. The RNA for each vehicle-control treated and glucose endothelin cortisol treated iPS derived cardiomyocytes from 4 replicate samples, were extracted and hybridized to 8 individual human HG-U133 Plus2.0 Affymetrix microarray gene chips, whereby each chip represented the expression profile for one cell culture at 2 days.

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Badi 

PROVIDER: E-GEOD-62203 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the condition using human-induced-pluripotent-stem-cell-derived cardiomyocytes. First, we mimic diabetic clinical chemistry to induce a phenotypic surrogate of diabetic cardiomyopathy, observing structural and functional disarray. Next, we consider genetic effects by deriving cardiomyocytes from two diabetic patient  ...[more]

Similar Datasets

Transcriptomics Effect of glucose, endothelin-1 and cortisol on human iPS-derived cardiomyocytes
2014-10-10 | GSE62203 | GEO
Genomics,Multiomics Homo sapiens
| PRJNA263469 | ENA
Genomics,Multiomics E-GEOD-62203
2014-10-27 | E-GEOD-62203 | ExpressionAtlas
Transcriptomics Effect of BET bromodomain inhibition with JQ1 in stressed human derived iPS cardiomyocytes
2017-03-30 | GSE96560 | GEO
Transcriptomics Transcription profiling by array of Rattus norvegicus cardiomyocytes to investigate the effects of PD184352 and BI-D1870 on changes in expression induced by endothelin-1
2013-01-16 | E-MEXP-3679 | biostudies-arrayexpress
Transcriptomics Transcriptional profiling of rat heart ventricular myocytes treated either with PD184352 alone or PD184352 and endothelin-1.
2010-05-26 | E-MEXP-2516 | biostudies-arrayexpress
Proteomics Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism
2017-07-14 | PXD006888 | Pride
Transcriptomics Microarray analysis of transcripts in the liver of gilthead sea bream with high plasma cortisol levels induced by slow-release cortisol implants
2011-07-19 | E-GEOD-30782 | biostudies-arrayexpress
Transcriptomics Salmonella Typhimurium: control vs. cortisol treatment
2011-07-25 | E-GEOD-30923 | biostudies-arrayexpress
Transcriptomics Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Cells
2018-05-30 | GSE110064 | GEO