S100 calcium-binding proteins A8/A9 initiate the early inflammatory program in injured peripheral nerve

ABSTRACT: To shed light on the early processes of immune response to peripheral nerve injury, we first used genome-wide transcriptional profiling and bioinformatics (Ingenuity, NextBio) pathway analyses of the proximal (P; regenerating) and distal (D; degenerating) nerve stumps at day 1 in the sciatic nerve axotomy model in rats. We identified a number of specific immunomodulatory genes and pathways that were regulated shortly post-injury in both the P and D segments, including all members of the interleukin (IL), chemokine, tumor necrosis factor (TNF), matrix metalloproteinase (MMP), toll-like receptor (TLR), tissue inhibitor of metalloproteinase (TIMP), ion channel and myosin families. Immunomodulatory calcium-binding S100A8 and S100A9 were the top up-regulated genes in both the D and P segments.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Andrei Chernov 

PROVIDER: E-GEOD-62282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress