Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell type specificity

ABSTRACT: Background: Although genome-wide association studies (GWAS) have identified hundreds of variants associated with risk of autoimmune and immune-related disorders (AID), our understanding of the diseases mechanisms is limited. In particular, more than 90% of the risk variants lie in non-coding regions, and almost 10% of these map to long non-coding RNA transcripts (lncRNAs). LncRNAs are known to show more cell-type specificity than protein-coding genes. Methods: In this study, we aimed to characterize lncRNAs and protein-coding genes located in loci associated with nine AID which have been well-defined by Immunochip analysis, by transcriptome analysis across seven peripheral blood leukocyte populations (granulocytes, monocytes, NK cells, B-cells, memory-T cells, naive CD4+ and naive CD8+ T-c

ORGANISM(S): Homo sapiens

SUBMITTER: Barbara Hrdlickova 

PROVIDER: E-GEOD-62408 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress