Differential Roles of ERM-NM-1 and ERM-NM-2 in Normal and Neoplastic Development in the Mouse Mammary Gland

ABSTRACT: The present experiments were performed to determine the roles of estrogen receptors M-NM-1 and M-NM-2 (ERM-NM-1 and ERM-NM-2) in normal and neoplastic development in the mouse mammary gland. In wild-type mice, in vivo administration of estradiol (E) + progesterone (P) stimulated mammary ductal growth and alveolar differentiation. Mammary glands from mice in which the ERM-NM-2 gene has been deleted (M-NM-2ERKO mice) demonstrated normal ductal growth and differentiation in response to E + P. By contrast, mammary glands from mice in which the ERM-NM-1 gene has been deleted (M-NM-1ERKO mice) demonstrated only rudimentary ductal structures that did not differentiate in response to E + P. EGF demonstrates estrogen-like activity in the mammary glands of M-NM-1ERKO mice: treatment of M-NM-1ERKO mi

ORGANISM(S): Mus musculus

SUBMITTER: Michael Falduto 

PROVIDER: E-GEOD-62451 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress