Transcription profiling of rat lung to investigate trauma hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes

ABSTRACT: The etiology of trauma-hemorrhage shock-induced acute lung injury has been difficult to elucidate due, at least in part, to the inability of in vivo studies to separate the non-injurious pulmonary effects of trauma-hemorrhage from the tissue injurious ones. To circumvent this in vivo limitation, we utilized a model of trauma-hemorrhagic shock (T/HS) in which T/HS-lung injury was abrogated by dividing the mesenteric lymph duct. In this way, it was possible to separate the pulmonary injurious response from the non-injurious systemic response to T/HS by comparing the pulmonary molecular response of rats subjected to T/HS which did and did not develop lung injury as well as to non-shocked rats. Utilizing high-density oligonucleotide arrays and treatment group comparisons of whole lung tissu

ORGANISM(S): Rattus norvegicus

SUBMITTER: Virginie Marie Aris 

PROVIDER: E-GEOD-6332 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress