GATA2 facilitates steroid receptor coactivator (SRC) recruitment to the androgen receptor (AR) complex

ABSTRACT: The androgen receptor (AR) is a key driver of prostate cancer (PC), even in the state of castration-resistant PC (CRPC), and frequently even after treatment with second-line hormonal therapies such as abiraterone and enzalutamide. The persistence of AR activity via both ligand-dependent and ligand-independent (including constitutively active AR splice variants) mechanisms highlights the unmet need for alternative approaches to block AR signaling in CRPC. We investigated the transcription factor GATA2 as a regulator of AR signaling and a novel therapeutic target in PC. We demonstrate that GATA2 directly promotes AR expression (both full-length and splice variant), resulting in a strong positive correlation between GATA2 and AR expression in PC (cell lines and patient specimens). Conversely,

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Mitsiades 

PROVIDER: E-GEOD-63539 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress