Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain

ABSTRACT: Background: Prenatal alcohol exposure (PAE) is associated with alterations in numerous physiological systems, including the stress and immune systems. We have previously shown that PAE increases the course and severity of arthritis in an adjuvant-induced arthritis (AA) model. While the molecular mechanisms underlying these effects are not fully known, changes in neural gene expression are emerging as important factors in the etiology of PAE effects. As the prefrontal cortex (PFC) and hippocampus (HPC) play key roles in neuroimmune function, PAE-induced alterations to their transcriptome may underlie abnormal steady-state functions and responses to immune challenge. The current study examined brains from adult PAE and control females from our recent AA study to determine whether PAE causes

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Kobor 

PROVIDER: E-GEOD-63561 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress