The Bile Response Repressor, BreR, Regulates Expression of the Vibrio cholerae breAB Efflux System Operon

ABSTRACT: Enteric pathogens have developed several resistance mechanisms to survive the antimicrobial action of bile. We investigated the transcriptional profile of Vibrio cholerae O1 El Tor strain C6706 under virulence gene inducing conditions, in the presence and absence of bile. Microarray analysis revealed that the expression of 119 genes was affected by bile. The mRNA levels of genes encoding proteins involved in transport was increased in the presence of bile, whereas mRNA levels of genes encoding proteins involved in pathogenesis and chemotaxis was decreased. This study identified genes encoding transcriptional regulators from the TetR family (vexR and breR) and multidrug efflux pumps from the RND superfamily (vexB and vexD [here renamed breB]) that were induced in response to bile. Further a

ORGANISM(S): Vibrio cholerae

SUBMITTER: Ronald Taylor 

PROVIDER: E-GEOD-6468 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress