Transcription profiling of human hyperdiploid multiple myeloma compared to non hyperdiploid multiple myeloma

ABSTRACT: Multiple myeloma is a relatively common B-cell malignancy that is currently incurable. Certain recurrent genetic abnormalities characteristics of different genetic subtypes have been described. Hyperdiploid myeloma characterized by recurrent trisomies is the most common genetic subtypes. However little is know about it's biology. Another common genetic abnormality is chromosome 13 deletion which is also associated with inferior prognosis. This abnormality is already present at the pre-malignant MGUS stage and is clonally selected with disease progression. Although it is biologically and clinically important the molecular consequence of chromosome 13 deletion is unknown. Experiment Overall Design: Hyperdiploid myeloma was identified using FISH. The gene expression profile of hyperdiploid MM

ORGANISM(S): Homo sapiens

SUBMITTER: Rafael Fonseca 

PROVIDER: E-GEOD-6477 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress