IL-10 production and metabolic regulation in macrophages are linked by a TLR-driven CREB-mediated mechanism

ABSTRACT: IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections macrophages are an important source of IL-10, however the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized. Here, bone marrow derived macrophages exposed to Excretory/Secretory (E/S) products released by Schistosoma mansoni cercariae rapidly produce IL-10 as a result of MyD88-mediated activation of MEK/ERK/RSK and p38. The phosphorylation of these kinases was triggered by TLR2 and TLR4 and converged on activation of the transcription factor CREB. Uptake of cercarial E/S products by phagocytosis was critical for the production of IL-10 and the activation of MAPKs and CREB, which indicates that interactions betwee

ORGANISM(S): Mus musculus

SUBMITTER: David Sanin Pena 

PROVIDER: E-GEOD-64844 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress