Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy

ABSTRACT: Although recent studies have revealed that microRNAs (miRNAs) regulate fundamental Natural Killer (NK) cell processes including cytotoxicity and cytokine production, little is known about the miRNA-gene regulatory relationships in maternal peripheral blood NK (pNK) cells during pregnancy. To predict the role of miRNAs within gene regulatory networks of maternal pNK cells during pregnancy, we performed comprehensive miRNA and gene expression profiling of maternal pNK cells using a combination of real-time PCR-based array and DNA microarray analyses and analyzed these differential expression levels between first- and third-trimester pNK cells. Furthermore, we constructed regulatory networks for miRNA-mediated gene expression in pNK cells during pregnancy by Ingenuity Pathway Analysis. By PCR

ORGANISM(S): Homo sapiens

SUBMITTER: Yoichi Ishida 

PROVIDER: E-GEOD-64884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress