Identification of NUCKS1 as a putative oncogene and immunodiagnostic marker of hepatocellular carcinoma

ABSTRACT: Purpose: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated mortality worldwide. Although the molecular mechanisms underpinning HCC are unknown, gene copy number and associated mRNA expression changes are frequently reported. Experimental Design: Comparative genomic hybridization arrays spotted with 4,041 bacterial artificial chromosome clones were used to assess copy number changes in 45 HCC tissues to identify chromosomal regions associated with the pathogenesis of HCC. Seventy more HCC tissues were used to validate candidate genes by using western blots and immunohistochemistry. Results: A total of 259 clones were associated with copy number changes that significantly differed between normal liver and HCC samples. The chromosomal region 1q32.1 containing

ORGANISM(S): Homo sapiens

SUBMITTER: Jaeyoun Cheong 

PROVIDER: E-GEOD-65237 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress