Next generation sequencing based transcriptomic analysis of oxidative stress response in Bifidobacterium longum BBMN68

ABSTRACT: Bifidobacterium longum strain BBMN68 is resistant to low concentrations of oxygen. In this study, a transcriptomic study was performed to detail the cellular response of B. longum strain BBMN68 to oxidative stress. Oxygen and its intermediate metabolites, reactive oxygen species (ROS), induced abundant changes in gene expression at the mRNA level. Increased expression was found for genes involved in ROS detoxification and the redox homeostasis system, protein and DNA synthesis and repair, the Fe–S cluster assembly system, and biosynthesis of branched-chain amino acids and tetrahydrofolate. Among them, two classes of ribonucleotide reductase (RNR), which are important for deoxyribonucleotide biosynthesis, were rapidly and persistently induced: first, the class Ib RNR NrdHIEF and then the

ORGANISM(S): Bifidobacterium longum

SUBMITTER: Fanglei Zuo 

PROVIDER: E-GEOD-65320 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress