Dynamics and Function of Distal Regulatory Elements during Neurogenesis and Neuroplasticity

ABSTRACT: Gene regulation in mammals involves a complex interplay between promoter and distal regulatory elements that function in concert to drive precise spatio-temporal gene expression programs. However, the dynamics of distal gene regulatory elements and its function in transcriptional reprogramming that underlies neurogenesis and neuronal activity remain largely unknown. Here we use a combinatorial analysis of genomewide datasets for chromatin accessibility (FAIRE-Seq) and enhancer mark H3K27ac to reveal a highly dynamic nature of chromatin accessibility during neurogenesis that gets restricted to certain genomic regions as neurons acquire a post-mitotic, terminally differentiated state. We further reveal that the distal open regions serve as target sites of distinct transcription factors that

ORGANISM(S): Mus musculus

SUBMITTER: Sudhir Thakurela 

PROVIDER: E-GEOD-65713 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress