Unknown,Transcriptomics,Genomics,Proteomics

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Expression data of embryonic kidney from MWF E15.5 and SHR 16.0 rats

ABSTRACT: Defects in nephrogenesis can have detrimental effects on cardiovascular and renal health in adult life. This is confirmed by observations in the Munich Wistar Frömter (MWF) rat that exhibits a congenital nephron deficit and renal failure with age. We performed genome-wide transcriptome analysis in embryonic kidneys to identify candidate genes for the reduced nephron number in MWF. We compared MWF E15.5 with stage-matched spontaneously hypertensive rats (SHR) at E16. Microarray analysis revealed 311 transcripts representing 253 known genes with differential expression between MWF and SHR (FC >+1.5 or <-1.5, FDR<0.05). 8 samples were analyzed, n=4 per group

ORGANISM(S): Rattus norvegicus

SUBMITTER: Reinhold Kreutz

PROVIDER: E-GEOD-66079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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