Expression and functions of long noncoding RNAs during human T helper cell differentiation

ABSTRACT: To improve our understanding of lncRNA expression in T cells, we used whole genome sequencing (RNA-seq) to identify lncRNAs expressed in human T cells and those selectively expressed in T cells differentiated under TH1, TH2, or TH17 polarizing conditions. The majority of these lineage-specific lncRNAs are co-expressed with lineage-specific protein-coding genes. These lncRNAs are predominantly intragenic with co-expressed protein-coding genes and are transcribed in sense and antisense orientations with approximately equal frequencies. Further, genes encoding TH lineage specific mRNAs are not randomly distributed across the genome but are highly enriched in the genome in genomic regions also containing genes encoding TH lineage-specific lncRNAs. Our analyses also identify a cluster of an

ORGANISM(S): Homo sapiens

SUBMITTER: Charles Spurlock III 

PROVIDER: E-GEOD-66261 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress