Nitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications [HiSeq 2000]

ABSTRACT: Dynamic changes in histone posttranslational modifications (PTMs) are important regulators of chromatin structure and gene transcription in both normal and disease settings. Herein, we describe a novel signaling mechanism of nitric oxide (•NO) by demonstrating its ability to modulate gene expression via alteration of histone PTMs. Having established that •NO exposure induced differential expression of approximately 6500 genes, we set out to determine if there was an epigenetic component to their regulation. •NO exposure led to alterations in the global levels of acetyl and methyl modifications at numerous lysine residues on core histones H3 and H4. Residues H3K9me2/ac were examined further and determined to have differential distribution at various loci throughout the genome in respo

ORGANISM(S): Homo sapiens

SUBMITTER: Douglas Thomas 

PROVIDER: E-GEOD-66318 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress