Host Age is a Systemic Regulator of Gene Expression Impacting Cancer Progression

ABSTRACT: Given that aging is the major determinant of cancer incidence, and that cancer incidence is dictated in large part by processes modulating progression of existing subclinical cancers, we demonstrate that aging may be an organizing axis for identifying cancer progression-modulating processes. This would permit the broad understanding of the aging process to directly inform the question of what changes in aggregate host signaling favor cancer progression. Exploring this idea, a syngeneic murine Lewis lung cancer model in adolescent (68 days), young adult (143 days), middle-aged (551 days), and old (736 days) C57BL/6 mice was used to identify the signaling and functional processes varying significantly with host age. As anticipated, many of these specific endpoints proved to be major determin

ORGANISM(S): Mus musculus

SUBMITTER: Afshin Beheshti 

PROVIDER: E-GEOD-66414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress