Transcription profiling of mouse short term diet induced hyperlipidemia model response to lovastatin and fenofibrate

ABSTRACT: C57BL/6 mice were fed ad libitum for the first 5 days of the experiments with high fat high cholesterol (HFC) diet only. The next 7 days of the experiments mice were continuously fed on a HFC diet and simultaneously vehicle (control group), fenofibrate (100 mg/kg) or lovastatin (30 mg/kg) were orally daily administered. At the end of the experiment (day 12) fenofibrate and lovastatin significantly decreased plasma LDL levels, while plasma cholesterol levels were significantly decreased by lovastatin only. Gene expression analysis of hyperlipidemic mouse liver revealed 391 significantly modulated genes when compared to standard diet fed mice. KEGG pathways related to modulated genes were identified and the most significant were biosynthesis of steroids, metabolism of xenobiotics by cytochro

ORGANISM(S): Mus musculus

SUBMITTER: Drago Kuzman 

PROVIDER: E-GEOD-6652 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress