Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

ABSTRACT: Disruption of local iron homeostasis is a common feature of neurodegenerative diseases. We focused on dopaminergic neurons, asking how iron transport proteins modulate iron homeostasis in vivo. Inactivation of the transmembrane iron exporter ferroportin had no apparent consequences. However, loss of the transferrin receptor 1, involved in iron uptake, caused profound, age-progressive neurodegeneration with features similar to Parkinson’s disease. There was gradual loss of dopaminergic projections in the striatum with subsequent death of dopaminergic neurons in the substantia nigra. After depletion of 30% of the neurons the mice developed neurobehavioral parkinsonism, with evidence of mitochondrial dysfunction and impaired mitochondrial autophagy. Molecular analysis revealed strong signatur

ORGANISM(S): Mus musculus

SUBMITTER: Pavle Matak 

PROVIDER: E-GEOD-66730 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress