Transcription profiling of mouse model of heart failure rescued by beta-adrenergic receptor kinase (betaARKct), vs heart failure and untreated samples

ABSTRACT: Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac function. We have recently demonstrated that several of these can be "rescued" or prevented by transgenic cardiac expression of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARKct). To uncover genomic changes associated with cardiomyopathy and/or its phenotypic rescue by the betaARKct, oligonucleotide microarray analysis of left ventricular (LV) gene expression was performed in a total of 53 samples, including 12 each of Normal, HF, and Rescue. Multiple statistical analyses demonstrated significant differences between all groups, and further demonstrated that betaARKct Rescue returned gene expression toward that of Normal. In our statistical analyse

ORGANISM(S): Mus musculus

DISEASE(S): normal transgenic (transgenic betaARKct)

SUBMITTER: Burns Blaxall 

PROVIDER: E-GEOD-670 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress