Proteomics

Dataset Information

24

Dynamic adaptation of myocardial proteome during heart failure development after induction of left ventricular pressure overload in mice


ABSTRACT: We analyzed time dependent global proteomic adaptations during heart failure (HF) progression in a mouse model, suffering from left ventricular pressure overload due to transverse aortic constriction (TAC), to gain deeper insights in the disease development and identify new biomarker candidates. The hearts from TAC and sham mice were examined by cardiac MRI on either day 4, 14, 21, 28, 42, and 56 after surgery (n=6 group/time point). At each time point, proteomes of the left (LV) and right ventricles (RV) of TAC and sham mice were analyzed by mass spectrometry (MS).

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus musculus  

TISSUE(S): Heart

DISEASE(S): Heart Failure

SUBMITTER: Alexander Benkner  

PROVIDER: PXD007171 | Pride | 2018-07-16

REPOSITORIES: Pride

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Publications

Dynamic adaptation of myocardial proteome during heart failure development.

Rüdebusch Julia J   Benkner Alexander A   Poesch Axel A   Dörr Marcus M   Völker Uwe U   Grube Karina K   Hammer Elke E   Felix Stephan B SB  

PloS one 20171003 10


Heart failure (HF) development is characterized by huge structural changes that are crucial for disease progression. Analysis of time dependent global proteomic adaptations during HF progression offers the potential to gain deeper insights in the disease development and identify new biomarker candidates. Therefore, hearts of TAC (transverse aortic constriction) and sham mice were examined by cardiac MRI on either day 4, 14, 21, 28, 42, and 56 after surgery (n = 6 per group/time point). At each t  ...[more]

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