Transcriptomic landscape of lncRNAs in Inflammatory Bowel Disease

ABSTRACT: Inflammatory bowel disease (IBD) is a complex multi-factorial inflammatory disease with Crohn’s disease (CD) and ulcerative colitis (UC) being the two most common forms. A number of transcriptional profiling studies have provided compelling evidence that describe the role of protein-coding genes and microRNAs in modulating the immune responses in IBD. In the present study, we performed a genome-wide transcriptome profiling of lncRNAs and protein-coding genes in inflamed and non-inflamed colon pinch biopsies from the IBD patients using expression microarrays platform. In this study, we identified widespread dysregulation of lncRNAs and protein-coding genes in both inflamed and non-inflamed CD and UC compared to the healthy controls. In case of inflamed CD and UC (iCD and iUC), we identifie

ORGANISM(S): Homo sapiens

SUBMITTER: Aashiq Mirza 

PROVIDER: E-GEOD-67106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress