Transcription profiling of rat heart and adipose tissue response to aging and caloric restriction in

ABSTRACT: Sustained caloric restriction (CR) extends lifespan in animal models but the mechanism and primary tissue target(s) have not been identified. Gene expression changes with aging and CR were examined in both heart and subcutaneous white adipose tissue (WAT) of F344 male rats using Affymetrix® RAE 230 arrays and validated by qRT-PCR on 18 genes. In heart, age- associated changes but not CR-associated changes in old. In WAT, genes were identified where the aging change is suppressed by CR (candidate markers of healthy aging) and those affected by CR but not normal aging (candidate longevity assurance genes). 10-21% of age-associated genes were regulated in common between tissues. Gene set enrichment analysis (GSEA) revealed coordinate small magnitude changes in ribosomal, proteasomal, and mit

ORGANISM(S): Rattus norvegicus

SUBMITTER: Richard Beyer 

PROVIDER: E-GEOD-6718 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress