Sustained L-type Calcium Channel Blockade Alters Gene Regulation in the Adult Mouse Ventricle

ABSTRACT: Objective: L-type calcium channels (LTCC) homeostatically regulate calcium on a beat by beat basis, but also provide Ca that over long time scales may contribute to transcriptional regulation. We previously showed that sustained LTCC blockade (CCB) elicits LTCC remodeling in ventricular cardiac myocytes (CM). Here we hypothesize that sustained CCB has broad effects on the expression of genes involved in calcium handling. Methods and Results: Therefore, we subjected adult mice to sustained CCB for 24 hours and performed gene expression profiling. In comparison to vehicle-only control animals, 231 genes were up-regulated, and 111 genes were down-regulated by sustained LTCC blockade (p <0.01). Gene ontology analysis suggested that the CaMKIIdelta signaling pathway was up-regulated in the

ORGANISM(S): Mus musculus

SUBMITTER: Elizabeth Schroder 

PROVIDER: E-GEOD-8367 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress