Identification of Dysregulated Long Noncoding RNAs in the Midbrain of Human Cocaine Abusers

ABSTRACT: Maintenance of the drug-addicted state involves changes in gene expression in different neuronal cell types and neural circuits. Midbrain dopamine neurons in particular mediate numerous responses to drugs of abuse. Long noncoding RNAs (lncRNAs) regulate CNS gene expression through a variety of mechanisms, but very little is known about their role in drug abuse. The proportion of lncRNAs that are primate-specific provides a strong rationale for their study in human drug abusers. We examined the profile of lncRNA expression in postmortem human midbrain specimens from chronic cocaine abusers and well-matched control subjects (n=11 subject pairs) using a custom lncRNA microarray. Differential expression was validated by quantitative PCR, and cellular localization investigated by in situ hybrid

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Bannon 

PROVIDER: E-GEOD-67281 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress