Regulation of Gene Expression Dynamics during Developmental Transitions by the Ikaros Transcription Factor

ABSTRACT: The DNA-binding protein, Ikaros, functions as a potent tumor suppressor and hematopoietic regulator. However, the mechanisms by which Ikaros functions in the nucleus remain largely undefined, due in part to its atypical DNA-binding properties and partnership with the poorly understood Mi-2/NuRD complex. In this study, we extended our analysis of thymocyte development and lymphomagenesis in a mouse strain containing a specific deletion of Ikaros zinc finger 4, which exhibits a select subset of abnormalities observed in Ikaros null mice. By examining thymopoiesis in vivo and in vitro, numerous abnormalities were observed. RNA-sequencing revealed that each developmental stage is characterized by mis-regulation of a limited number of genes, with a strong preference for genes modulated in a sta

ORGANISM(S): Mus musculus

SUBMITTER: Teresita Arenzana 

PROVIDER: E-GEOD-67572 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress