46,XY sex reversed females with complete androgen insensitivity syndrome

ABSTRACT: This gene set contains skin fibroblasts from either labia majora of 46,XY sex reversed females having complete androgen insensitivity syndrome due to inactivation mutations of the androgen receptor gene and from the scrotum of normal males. Both, labia majora and scrotum origin from the same embryological anlagen, the labioscrotal swellings. The phenotypic difference is due to androgen dependent virilization in males. This is not possible in 46,XY patients with complete androgen insensitivity syndrome because the androgen receptor pathway is knocked out. A cell type comparison design experiment design type compares cells of different type for example different cell lines. Cell Line: genital skin fibroblasts from different locations mutant line: normal 46,XY male and 46,XY sex reversed fema

ORGANISM(S): Homo sapiens

SUBMITTER: Paul-Martin Holterhus 

PROVIDER: E-GEOD-6797 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress