Transcription profiling of human skeletal muscle of women with PCOS reveals reduced expression of mitochondrial oxidative metabolism genes

ABSTRACT: Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. To identify pathways of importance for the pathogenesis of insulin resistance in PCOS, we performed biological pathway analysis using Gene Set Enrichment Analy

ORGANISM(S): Homo sapiens

SUBMITTER: Vibe Skov 

PROVIDER: E-GEOD-6798 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress