Escherichia coli global gene expression due ciprofloxacin challenge in laboratory medium and human serum

ABSTRACT: Treatment failures of antibiotic therapy are of major concern and can be caused by a misalignment of the antibiotic susceptibility determined in vitro with the behaviour of the pathogen in the patient. The aim of this study was to investigate the transcriptomic response of the uropathogenic strain E. coli CFT073 to antibiotic treatment in blood stream infection (BSI) models in order to understand and avoid antibiotic therapy failures in urosepsis treatments. Blood stream infection models were established by growing E. coli CFT073 in pooled human serum with and without ciprofloxacin and compared to Iso-sensitest medium. The antibiotic challenge was introduced at mid-logarithmic phase of growth of the organism to depict a clinical scenario . Global gene expression profiling of these conditio

ORGANISM(S): Escherichia coli CFT073

SUBMITTER: Senthil Gandi 

PROVIDER: E-GEOD-68105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress