Context- and cell-type specific function of miR155-Socs1 interaction in immune regulation

ABSTRACT: The microRNA (miRNA) dependent regulation of gene expression confers robustness to cellular phenotypes and controls responses to extracellular stimuli. Although a single miRNA can regulate expression of hundreds of target genes, it is unclear whether any of its distinct biological functions can be due to the regulation of a single target. To explore in vivo the function of a single miRNA-mRNA interaction, we mutated the 3' UTR of a major miR-155 target SOCS1 to specifically disrupt its regulation by miR-155. We found that under physiologic conditions and during autoimmune inflammation or viral infection some immunological functions of miR-155 were fully or largely attributable to the regulation of SOCS1, whereas others could be accounted only partially or not at all by this interaction. O

ORGANISM(S): Mus musculus

SUBMITTER: Yuheng Lu 

PROVIDER: E-GEOD-68511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress