Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Donald Dunbar
PROVIDER: E-GEOD-68515 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Qiu J J Dunbar D R DR Noble J J Cairns C C Carter R R Kelly V V Chapman K E KE Seckl J R JR Yau J L W JL
Journal of neuroendocrinology 20160101 1
Mice deficient in the glucocorticoid-regenerating enzyme 11β-HSD1 resist age-related spatial memory impairment. To investigate the mechanisms and pathways involved, we used microarrays to identify differentially expressed hippocampal genes that associate with cognitive ageing and 11β-HSD1. Aged wild-type mice were separated into memory-impaired and unimpaired relative to young controls according to their performance in the Y-maze. All individual aged 11β-HSD1-deficient mice showed intact spatial ...[more]