A mex3 homolog is required for differentiation during planarian stem cell lineage development

ABSTRACT: Neoblasts are adult stem cells (ASCs) in planarians which sustain cell replacement during homeostasis and regeneration of any missing tissue. While numerous studies have examined genes underlying neoblast pluripotency, molecular pathways driving the postmitotic fate remain poorly defined. Here we used transcriptional profiling of irradiation-sensitive and -insensitive cell populations and RNA interference (RNAi) functional screening to uncover markers and regulators of postmitotic progeny. We identified 32 new markers, which distinguish two epithelial progenitor populations, and a planarian homolog to the MEX3 RNA-binding protein (Smed-mex3-1) as a key regulator of lineage progression. mex3-1 is required for generating progenitors of epithelial, neural, eye, pharyngeal, and protonephr

ORGANISM(S): Schmidtea mediterranea

SUBMITTER: Bret Pearson 

PROVIDER: E-GEOD-68581 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress