Expression data from MLL-rearranged leukemia model

ABSTRACT: Chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene occur in primary and treatment-related leukemias, and confer a poor prognosis. Studies based primarily on mouse models have substantially advanced our understanding of MLL leukemia pathogenesis, but often employ supra-physiologic oncogene expression with uncertain implications for human leukemia. Genome editing using site-specific nucleases provides a powerful new technology for gene modification to potentially model human disease, however this approach has not been used to recreate acute leukemia in human cells of origin comparable to disease observed in patients. We applied TALEN-mediated genome editing to generate endogenous MLL-AF9 and MLL-ENL oncogenes through insertional mutagenesis in primary human hematopoi

ORGANISM(S): Homo sapiens

SUBMITTER: Corina Buechele 

PROVIDER: E-GEOD-68879 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress