CGH detection of chromosomal rearrangements in diploid yeast cells exposed to ionizing radiation

ABSTRACT: At the organismal level, genome rearrangements are usually deleterious and are often associated with disease. Yet, on an evolutionary scale, they can be beneficial as they provide for rapid genetic diversification. DNA lesions, particularly double-strand breaks (DSBs), are sources of genome instability that can be rectified by various repair processes. Homologous recombination (HR) is highly effective at protecting the genome from DSBs and provides for accurate repair between sister chromatids and homologous chromosomes. Here we show that although random DSBs induced by ionizing radiation in yeast chromosomes are repaired efficiently by HR in G-2 diploid cells, rearrangements are frequent. The chromosome aberrations (ABs) primarily resulted from recombination between Ty retrotransposa

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Juan Lucas Argueso 

PROVIDER: E-GEOD-6984 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress