Long non-coding RNAs display higher natural expression variability than protein-coding genes in healthy humans

ABSTRACT: Background: Long non-coding RNAs (lncRNAs) are increasingly implicated as gene regulators and may ultimately be more numerous than protein-coding genes in the human genome. Despite large numbers of reported lncRNAs, reference annotations are likely incomplete due to their lower and tighter tissue-specific expression compared to mRNAs. An unexplored factor potentially confounding lncRNA identification is inter-individual expression variability. Here, we characterize lncRNA natural expression variability in human primary granulocytes. Results: We annotate granulocyte lncRNAs and mRNAs in RNA-seq data from ten healthy individuals, identifying multiple lncRNAs absent from reference annotations, and use this to investigate three known features (higher tissue-specificity, lower expression, and

ORGANISM(S): Homo sapiens

SUBMITTER: Aleksandra E Kornienko 

PROVIDER: E-GEOD-70390 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress