Gene expression in zebrafish following knockdown of pitx2 or tbx5

ABSTRACT: Key regulators of septum formation between the left and right ventricle in mammals, including the transcription factors TXB5 and PITX2, feature loss-of-function phenotypes that affect development of the two-chambered zebrafish heart, suggesting uncharacterized primordial functions of these septation regulators prior to the evolution of any physical boundaries between heart chambers. Data is as published in Mosimann & Panakova et al (Nature Communications, 2015) Samples for tbx5a versus pitx2ab MO comparison were collected from three independent experiments of MO-injected siblings and uninjected wildtype controls at 56hpf by morphology.

ORGANISM(S): Danio rerio

SUBMITTER: Gabriel Musso 

PROVIDER: E-GEOD-70750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress