Placental transcriptomic pattern of murine advanced paternal age model of autism

ABSTRACT: Advanced paternal age has been shown to be a significant risk factor for neurodevelopmental psychiatric disorders, particularly autism. We have recently shown that mice conceived by old fathers display behavioral abnormalities which resemble key diagnostic symptoms of human autism. De novo mutations and epigenetic alterations increase in the male germ line during ageing and are thought to mediate the effect of paternal age on occurrence of diseases occurrence. Because the placenta carry a predominantly fetal genetic background, age-related mutagenesis and epigenetic errors might negatively influence placental physiology and in turn perturb fetal brain development. Here, we examined the impact of paternal age on placental mRNA transcriptome. This work was supported by Programme FP7-KBBE-

ORGANISM(S): Mus musculus

SUBMITTER: Adrian Stankiewicz 

PROVIDER: E-GEOD-71322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress