Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas


ABSTRACT: We used gene transcript profiling to gain a deeper understanding of the role of FBXW7 in tumor development and to determine the influence of mTOR inhibition by rapamycin on tumor transcriptome and biological functions. In comparison to tumors from p53 single heterozygous (p53+/-) mice, we find that tumors from Fbxw7/p53 double heterozygous (Fbxw7+/-p53+/-) mice show significant deregulation of cholesterol metabolic processes independent of rapamycin treatment, while cell cycle related genes were upregulated in tumors from placebo treated Fbxw7+/-p53+/- mice, but not in tumors from rapamycin treated Fbxw7+/-p53+/- mice. On the other hand, tumors from rapamycin treated Fbxw7+/-p53+/- mice were enriched for genes involved in the integrated stress response, an adaptive mechanism to survive in stressful environments. p53+/− and p53+/−Fbxw7+/− mice were generated by crossing p53-/- mice with Fbxw7+/- mice. At 5 weeks of age, mice were exposed whole-body to a single dose of 4 Gy X-ray irradiation. Mice were divided randomly into two groups and treated with rapamycin or placebo. RNA was isolated from thymic lymphomas.

ORGANISM(S): Mus musculus

SUBMITTER: Antoine Snijders 

PROVIDER: E-GEOD-71975 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2015-10-31 | GSE71975 | GEO
2013-03-01 | E-GEOD-44733 | biostudies-arrayexpress
2017-10-16 | GSE102246 | GEO
2018-10-26 | PXD005845 | Pride
2008-06-15 | E-GEOD-7607 | biostudies-arrayexpress
2013-05-10 | E-GEOD-46797 | biostudies-arrayexpress
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
2013-09-06 | E-GEOD-43546 | biostudies-arrayexpress
2015-03-05 | ST000312 | MetabolomicsWorkbench
2015-09-17 | GSE69213 | GEO