Transcription profiling of human LNCaP cell lines transfected with AIbZIP

ABSTRACT: Androgen-induced bZIP (AIbZIP) is a basic leucine zipper (bZIP); transcription factor that is encoded by the CREB3L4 (cAMP responsive element; binding protein 3-like 4) gene. In humans, AIbZIP mRNA is most abundant in; the prostate but it is also present, albeit at much lower levels, in the; pancreas and other tissues. The full-length AIbZIP protein localizes to the; endoplasmic reticulum and the available data suggest that AIbZIP is; processed to its transcriptionally active form by regulated intramembrane; proteolysis (RIP). To define the transcriptional programme that is initiated; by AIbZIP, we generated LNCaP prostate cancer cell lines that conditionally; express the processed form of AIbZIP. The recombinant protein consists of; the first 290 amino acids of AIbZIP fused to a C-termina

ORGANISM(S): Homo sapiens

SUBMITTER: Ezequiel Calvo 

PROVIDER: E-GEOD-7223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress