TCDD-induced hepatic transcriptomic responses in transgenic AHR-variant mice

ABSTRACT: The aryl hydrocarbon receptor (AHR) mediates most of the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, TCDD toxicity phenotypes vary widely between species, strains and even between sexes within a strain. While the exact reasons for this variation remain unclear, it is thought to be related to differences in the structure of the AHR. Previous studies comparing the downstream effects of TCDD exposure between animals with different AHR isoforms have been confounded by the genetic differences between these model systems. To address this issue conclusively, we evaluated three transgenic mouse lines, each of which express a different rat AHR isoform (rWT, DEL, and INS) from two strains of rat with highly divergent TCDD-susceptibilities, within identical genetic backgroun

ORGANISM(S): Mus musculus

SUBMITTER: Stephenie Prokopec 

PROVIDER: E-GEOD-72270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress