Integrative fine-mapping of regulatory variants and mechanisms at coronary artery disease loci

ABSTRACT: Coronary artery disease (CAD) is the leading cause of mortality and morbidity driven by both genetic and environmental risk factors. Meta-analyses of genome-wide association studies (GWAS) have identified multiple single nucleotide polymorphisms (SNPs) associated with CAD and myocardial infarction (MI) susceptibility in multi-ethnic populations. The majority of these variants reside in non-coding regulatory regions and are co-inherited with hundreds of candidate regulatory SNPs. Herein, we use integrative genomic, epigenomic, and transcriptomic fine-mapping in human coronary artery smooth muscle cells (HCASMC) and tissues to identify causal regulatory variation and mechanisms responsible for CAD associations. Using these genome-wide maps we prioritize 65 candidate variants and perform alle

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Quertermous 

PROVIDER: E-GEOD-72696 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress