Transcription profiling of rat model of aging - progressive aortic vasculopathy

ABSTRACT: This study utilized a standard rat model of aging and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Recent studies have established that age is the major risk factor for vascular disease. Numerous changes occur in vascular structure and function during aging, and animal models, including rodents, are the primary means to determine the underlying mechanisms of age-mediated vascular pathology. This study utilized a standard rat model of aging and both morphometric and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Morp

ORGANISM(S): Rattus norvegicus

SUBMITTER: Steven Miller 

PROVIDER: E-GEOD-7281 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress